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Higher concentrations of these elements were found in smokers [130], as also evidenced by the results of Dróżdż et al

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Xenobiotic metabolism, developmental processes, and treatment responses vary in every individual due to epigenetic modifications, such as DNA methylation, histone modifications, and non-coding RNA regulation, as they play a substantial role in influencing CYP450 enzyme activity ( CYP expression is further modulated by ligand-activated receptors such as the aryl hydrocarbon receptor (AhR), pregnane X receptor (PXR), and constitutive androstane receptor (CAR), which control a hepatoprotective gene network in the liver and intestine ( This receptor-mediated transcriptional regulation represents a primary mechanism by which the exposome dynamically modulates CYP450 enzyme activity, thereby profoundly impacting drug metabolism and response