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Commonly reported: Mild injection-site reactions (redness, swelling, or tenderness), typically resolving within 24 to 48 hours Occasional mild headaches Transient fatigue during the initial days of use Not observed in clinical trials: No elevation of IGF-1 levels No impairment of glucose tolerance or carbohydrate metabolism No insulin resistance No anti-AOD-9604 antibody formation No fluid retention or joint pain No serious adverse events attributed to AOD-9604 Important limitations: The longest clinical trial duration was 24 weeks, and no data exist on effects beyond six months of use

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Without that, use is off-label and uncoupled from systematic safety monitoring

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