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a G protein-coupled receptor that mediates vision in dim light by controlling activity of transducin, a G protein an enzyme that catalyzes the conversion of ATP into cytoplasmic 3',5'-cyclic adenosine monophosphate (cAMP) an ion channel that allows transmembrane passage of calcium ions in a manner that is regulated the membrane voltage gradient proteins that bind G protein-coupled receptors to inhibit signaling through G protein activation and ultimately, to permanently terminate signaling by promoting endocytotic internalization and degradation of the receptor

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Under physiological conditions, endogenous RONS are generated by enzymatic systems, including nicotinamide adenine dinucleotide phosphate oxidase (NADPH oxidase) and nitric oxide synthase (NOS), as a by-product of mitochondrial electron transport chain reactions (Figure 1) or by metal-catalyzed oxidation [37,38]

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