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Recent studies have demonstrated that modulation of the gut microbiota can reduce seizure frequency, alleviate depressive symptoms, and suppress neuroinflammatory responses, suggesting that GBA-targeted interventions represent a promising therapeutic direction for EDC (He et al., 2024)

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Although there are currently no large-scale clinical trials of DPP1 inhibitors specifically for COPD, based on positive results in bronchiectasis studies and mechanism of action analysis, DPP1 inhibitors are expected to provide new treatment options for COPD patients, particularly those with neutrophil inflammation as the main characteristic phenotype may achieve more significant therapeutic benefits