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2 Shanghai Research Institute of Acupuncture and Meridian, Shanghai University of Traditional Chinese Medicine, Shanghai, People’s Republic of China *These authors contributed equally to this work Correspondence: Yanting Yang, Shanghai Research Institute of Acupuncture and Meridian, Shanghai University of Traditional Chinese Medicine, 650 Wanping South Road, Shanghai, 200030, People’s Republic of China, Email [email protected] Xiaopeng Ma, Shanghai Research Institute of Acupuncture and Meridian, Shanghai University of Traditional Chinese Medicine, 650 Wanping South Road, Shanghai, 200030, People’s Republic of China, Email [email protected] Purpose: To study the knowledge structure and evolution of oxidative stress in dry eye disease (DED) using bibliometrics and explore prospective anti-oxidative stress strategies for future clinical interventions