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Weight of evidence: Overall evidence is Low-Moderate: multiple animal studies and a growing number of small clinical trials suggest benefits across gut–brain signaling, social and behavioral domains, gastrointestinal symptoms, and neurophysiological patterns, yet most human studies rely on caregiver-reported outcomes, lack biomarker integration, and seldom control for diet, comorbidities, or baseline microbiome composition
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Under conditions of certain cancer types, chronic mild stress, or metabolic disorders of amino acids, including glycine, homocysteine, and S-adenosylmethionine, there is an observed increase in methylation of the GPX4 promoter, which leads to GPX4 inhibition and resultant ROS accumulation, thus inducing ferroptosis [37-41]
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