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The formation of intramolecular disulfide bonds during the maturation of many secreted proteins and membrane proteins requires not only the GRP78 chaperone protein but also the involvement of PDI and ER redox protein 1 (ERO1)
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mTOR is integral for the metabolic reprogramming of T cells to increase membrane expression of nutrient transporters, which augment uptake of nutrients that are utilized for energy production and macromolecule synthesis (428, 429)
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