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An individual gene analysis showed that ATF4 inhibition resulted in decreased expression of key genes encoding enzymatic regulators of the SSP, one-carbon metabolism, cysteine synthesis, glutamate and aspartate metabolism, alanine synthesis, branched chain amino acid (BCAA) catabolism, arginine and proline synthesis, the TCA cycle, as well as multiple amino acid transporters (e.g., SLC1A4, SLC1A5, SLC6A9, SLC7A1, SLC7A2, SLC7A5, SLC7A11, SLC38A1, SLC38A2, SLC43A1)

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Maechler et al., 2006