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glutathione mitochondrial membrane potential GSH How Long Does Alcohol
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In addition, APP/PS1 mice, which are double transgenic mice expressing a chimeric mouse/human APP and a mutant human presenilin 1, display increased apathy-like behaviors compared to wild-type mice (Pugh et al., 2007
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5) Unlike the neuropsychiatric disorders, in which Glu-GSH dysregulation primarily reflects a failure of homeostatic defense, cancer cells actively co-opt and amplify the Glu-GSH axis as a pro-survival resource: constitutively elevated GSH biosynthesis, driven by reprogrammed glutamine catabolism and context-dependent transcriptional rewiring, simultaneously fuels proliferation, shields cells from oxidative stress, amplifies mitogenic signaling, and remodels the tumor immune microenvironment
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