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Interestingly, several studies showed that cytokines and stress stimuli such as TNF-α, interleukins, FAS ligand, heat shock, UV irradiation and also stressors that deplete glutathione such as ROS and 4HNE can activate sphingomyelinase, which leads to increased ceramide production 58,59,60
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Jobling, R
This product is not intended to diagnose
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