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Interestingly, the extract induced a sub-G1 population, indicating necrotic cell death rather than apoptosis, while also demonstrating reduced intracellular iron concentrations, suggesting that, similar to what occurs on humans and animals models like mice, artemisinin-induced cell death in other animal species may occur via ferroptosis, a programmed cell death mechanism associated with lipid peroxidation and oxidative stress [148,149,150,151]

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Lancet Planet Health 2 , e521–e531 (2018)