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The original vaccine series most Americans received earlier in the pandemic is no longer available: Earlier, monovalent formulations from Moderna and Pfizer are no longer authorized in the US, and others, like Novavax and Johnson and Johnson’s, have been used here only infrequently

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For example, subunit vaccines that can elicit S-specific neutralizing antibodies should present lower ADE risks (especially against S stabilized in the prefusion conformation, to reduce the presentation of non-neutralizing epitopes 8 )