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[3] The review's bottom line was blunt: 'The primary barrier to clinical translation is not the absence of biological activity, but the absence of fundamental pharmaceutical science.' Eric Topol, in a July 2025 Substack piece on the broader peptide market, placed BPC-157 alongside other non-approved compounds and stated that 'there is no evidence from randomized trials in humans that any of these peptides provide the benefits that are advocated.' He also flagged the theoretical cancer-risk signal from BPC-157's angiogenic mechanism, specifically its promotion of VEGF expression and new blood vessel growth, as an area that warrants human data before wide clinical use