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Mechanistically, TSA targeted PGK1 (a key glycolytic enzyme) to inhibit its binding to mitochondria, reducing PDHK1 (pyruvate dehydrogenase kinase 1) activity, restoring mitochondrial function and reprogramming macrophage metabolism
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In such cases, intravenous magnesium administration may offer better tolerance and efficacy, typically using 8–12 grams of magnesium sulfate within the first 24 h, followed by 4–6 grams daily for 3 to 4 days (94)
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