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Specifically, leaky gut is often associated with: Chronic diarrhea or constipation Gas and bloating Nutritional deficiencies Sugar or carbohydrate cravings Fatigue Headaches Difficulty concentrating Joint pain and other forms of inflammation Some people believe that a leaky gut on its own is the cause of their GI problems, referring to it as “leaky gut syndrome.” While the theory that it’s a separate diagnosable disease is becoming more popular, it hasn’t really been embraced in contemporary Western medicine, and leaky gut syndrome isn’t typically something with which a doctor will diagnose you

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Evidence level: Mechanism exceeds clinical evidence How to read this: Cellular NAD+ changes in cultured adipocytes do not establish a human clinical benefit