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With intramuscular (IM) injections —the standard treatment for severe deficiency or malabsorption conditions like pernicious anaemia—serum B12 levels rise rapidly, typically reaching therapeutic ranges within 24–48 hours after the first injection

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National Academy of Medicine estimate that there are approximately 836,000 to 2.5 million (2, 9) individuals diagnosed with ME/CFS in the U.S., with a quarter of these patients thought to be housebound or bedbound (10)