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The study found that NNMT inhibitors "reduced intracellular 1-MNA, increased intracellular NAD+ and S-(5′-adenosyl)-L-methionine (SAM), and suppressed lipogenesis." This metabolic improvement occurs within days of starting treatment, before any weight loss becomes measurable

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however, this decrease is accompanied by the downregulation of proferroptotic factors and the upregulation of HSF1 (Peng et al., 2023)

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