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In addition, the GRM7 SNP rs11928865 (TT) gene is more common in specific types of Chinese elderly Han Chinese male patients with ARHL, and this finding may aid in the clinical screening and classification of ARHL patients (Friedman et al., 2009
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From a translational perspective, itaconate and its derivatives have demonstrated protective potential across multiple disease models, but their pharmacokinetics, tissue distribution, therapeutic window, and delivery efficiency remain key barriers to clinical application
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