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In this species, inflammatory bowel disease (IBD), alimentary lymphoma, pancreatitis, cholangitis/cholangiohepatitis [29,30,35], and exocrine pancreatic insufficiency (EPI) [55] are the diseases frequently associated with cobalamin deficiency [29,30,35]
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→ Practical Interpretation The mechanistic plausibility (NNMT → ↑NAD⁺ → ↑SIRT1/PGC-1α → ↑BMR & fat oxidation) is strong and consistent across preclinical models
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