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established a chemical cocktail of CHIR, A8301, and SAG (a Hedgehog signaling activator) combined with EGF, HGF and BMP4, which significantly promoted the expansion and stemness maintenance of HPCs (Pan et al., 2019)

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Short-chain fatty acids (SCFAs) inhibit lipid synthesis and enhance insulin sensitivity by increasing the DNA methylation of the miR-378a promoter (42, 43) (Figure 3D)