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As early as in the 1920’s, Otto Warburg discovered that cancer cells, despite the presence of oxygen, preferentially rely on glycolysis and lactate production rather than mitochondrial respiration, a metabolic reprogramming now known as “The Warburg effect” ( Figure 1 ) (84, 85)
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10.1161/01.CIR.0000069826.36125.B4 258 SalemM
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