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Encapsulating curcumin and other metabolites in hydrophilic polymers such as PHEMA or PLGA enhances anticancer activity (Pandey et al., 2025), suppressing tumor growth and modulating apoptotic and angiogenic markers (Bax, Bcl-2, survivin, VEGF, COX-2) and also signaling pathways such as NF-κB, JAK/STAT3, and PI3K/Akt (Zahra et al., 2022
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