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The 4-Hydroxynonenal–Protein Adducts and Their Biological Relevance: Are Some Proteins Preferred Targets?

In recent years, an increasing number of animal studies and preliminary clinical trials have investigated the impact of IF on fatty acid metabolism and the neuroimmune microenvironment, revealing its promising applications in neurodegenerative, autoimmune, and neurotraumatic diseases (30–33)

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Overall, therefore, this means that positive effects have been moderate, at best, when results are examined at the group level – at least using this currently accepted method for measuring cognition in neurodegenerative clinical trials

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