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Early work established that 1-MNAM increased Sirt1 protein levels and activity and therefore, suppressed fatty acid and cholesterol synthesis in hepatocytes, as well as decreased liver triglyceride and cholesterol concentrations [51]
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(2) Combinatorial mutations around the substrate binding pocket led to the identification of the most effective variant Pp PETase Y239R/F244G , which displays a 4.6-fold improvement in BHET degradation activity
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